When you smoke various cannabis strains there is almost always a different effect, no matter how small. This is due to a unique combination of terpenes and cannabionoids that vary from strain to strain.Those terpenes and cannabinoids give us an entourage effect.
This is why some indicas knock you out while others mellow you out and give you intense munchies. It is why some sativas give anxiety while others get you focused and energetic.
Watch this video to have a better understanding of the entourage effect.